I read with great interest your paper in Nature Medicine, and would
like to congratulate you for this important contribution against Covid.
As member (and fan) of the HCA, I would like to suggest you to add to
the *COVID-19 Cell Atlas *website our cell-sorted human gamma delta T
lymphocytes scRNASeq dataset (n=8k cells), freely available at NCBI GEO
data sets as *GSE128223*. The (cell, gene) matrix is included and
readily downloadable from this site, or else we can directly provide you
with if you prefer.
Here are 2 important reasons for adding it:
1-It is the only scRNASeq (10xgenomics Chem. 3' V2) resource available
for these human T cells, which were TCR purified by state of the art
2- gamma delta T lymphocytes are abundantly resident in all epithelia
and mucosal human tissues and mediate innate immunity resposnes.
If interested, read our paper by Pizzolato, G., et al. :
Single-cell RNA sequencing unveils the shared and the distinct
cytotoxic hallmarks of human TCRVdelta1 and TCRVdelta2 gammadelta T
lymphocytes. PNAS (2019): 116, 11906-11915.
Best regards, and bravo anyway
Jean Jacques Fournié, PhD
Cancer Research Center of Toulouse
CRCT-UMR1037 Inserm-Université Toulouse 3-ERL5294 CNRS
Oncopole de Toulouse, 2 Avenue Hubert Curien, CS 53717
31037 TOULOUSE CEDEX 1 - FRANCE
office: +335 8274 1590
mobile: +336 1990 0602